Theoretical analysis of T-wave polarity based on a model of cardiac electrical activity

Michitoshi Inoue, Masatsugu Hori, Fumihiko Kajiya, Hideo Kusuoka, Hiroshi Abe, Toshiyuki Furukawa, Seiichi Takasugi

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The effect of the gradient of transmembraneaction potential duration through the ventricular wall on T-wave polarity and QRS-T angle was investigated using a mathematical model of the electrical activity of the heart which incorporates the characteristic electrophysiological properties of the left ventricular wall. Two models, a rectangular solid model and a concave model, were constructed to simulate a part of the left ventricular wall. The ventricular gradient was defined as a linear decrease (β msec/cm) of the action potential duration from the endocardium to epicardium. The theoretically-obtained relationship between the QRS-T angle and the ventricular gradient revealed that the transmural gradient (β) was 10-40 msec/cm when the QRS-T angle was within the normal range. The positive T wave was obtained at the observation point which would correspond to the precordial lead when the transmural gradient was more than 30 msec/cm. The amplitude of the simulated T-wave increased with the ventricular gradient. Thus, our mathematical models can provide the quantitative relationship between the transmural ventricular gradient and T-wave polarity and are compatible with further simulation study for various pathological conditions.

Original languageEnglish (US)
Pages (from-to)171-180
Number of pages10
JournalJournal of Electrocardiology
Issue number2
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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