TY - JOUR
T1 - Theoretical analysis of effects of blood substitute affinity and cooperativity on organ oxygen transport
AU - Kavdia, Mahendra
AU - Pittman, Roland N.
AU - Popel, Aleksander S.
PY - 2002/12
Y1 - 2002/12
N2 - Hemoglobin-based O2 carriers (HBOCs), which are developed as an alternative to blood transfusion, provide O2 delivery. At present, there is no model to predict the O2 transport for a red blood cell-HBOC mixture on a whole organ basis. On the basis of the first principles of mass balance, a model of O2 transport for an organ was derived to calculate venous PO2 (PvO2 for a given inlet arterial PO2 (PaO2), blood flow, and oxygen consumption. The model was validated by using several in vivo animal studies on HBOC administration for a wide range of HBOC oxygen-binding parameters and predicted PvO2 for various PaO2 in the same species. The model was also used to predict the effect of HBOC affinity and cooperativity on PvO2 for humans. The results indicate that PvO2 can be increased at a constant blood flow-to-oxygen consumption ratio by reducing the affinity of HBOC for normoxia and mild hypoxia; however, a high-affinity HBOC would be more efficient in maintaining higher PvO2 for severe hypoxia (PaO2 < 40 Torr).
AB - Hemoglobin-based O2 carriers (HBOCs), which are developed as an alternative to blood transfusion, provide O2 delivery. At present, there is no model to predict the O2 transport for a red blood cell-HBOC mixture on a whole organ basis. On the basis of the first principles of mass balance, a model of O2 transport for an organ was derived to calculate venous PO2 (PvO2 for a given inlet arterial PO2 (PaO2), blood flow, and oxygen consumption. The model was validated by using several in vivo animal studies on HBOC administration for a wide range of HBOC oxygen-binding parameters and predicted PvO2 for various PaO2 in the same species. The model was also used to predict the effect of HBOC affinity and cooperativity on PvO2 for humans. The results indicate that PvO2 can be increased at a constant blood flow-to-oxygen consumption ratio by reducing the affinity of HBOC for normoxia and mild hypoxia; however, a high-affinity HBOC would be more efficient in maintaining higher PvO2 for severe hypoxia (PaO2 < 40 Torr).
KW - Cat
KW - Exchange transfusion
KW - Hamster
KW - Hemoglobin based oxygen carrier
KW - Oxygen affinity
KW - Oxygen dissociation curve
KW - Partial pressure of oxygen at 50% hemoglobin saturation
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U2 - 10.1152/japplphysiol.00676.2002
DO - 10.1152/japplphysiol.00676.2002
M3 - Article
C2 - 12391075
AN - SCOPUS:0036892639
SN - 8750-7587
VL - 93
SP - 2122
EP - 2128
JO - Journal of applied physiology
JF - Journal of applied physiology
IS - 6
ER -