The ways and means that fine tune Sirt1 activity

Javier R. Revollo, Xiaoling Li

Research output: Contribution to journalReview articlepeer-review

95 Scopus citations


Sirt1 is the most evolutionarily conserved mammalian sirtuin. It plays a vital role in the regulation of metabolism, stress responses, genome stability, and ultimately aging. Although much attention has focused on the identification of the cellular targets and functional networks controlled by Sirt1, the mechanisms that regulate Sirt1 activity by biological stimuli have only recently begun to emerge. As an enzyme, the activity of Sirt1 can be controlled by the availability of its substrates, post-translational modifications, interactions with other proteins, or changes in its expression levels. In this review, we briefly discuss the ways and means by which the activity of Sirt1 is fine-tuned under different conditions.

Original languageEnglish (US)
Pages (from-to)160-167
Number of pages8
JournalTrends in biochemical sciences
Issue number3
StatePublished - Mar 2013
Externally publishedYes


  • Aging
  • Energy metabolism
  • Metabolic sensor
  • Nutrients
  • Sirt1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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