@article{f8a0b4a80a754cf08130059727d8f397,
title = "The utility of pharmacokinetic studies for the evaluation of exposure-response relationships for standard dose anti-tuberculosis drugs",
abstract = "Tuberculosis (TB) is a major public health problem. Many countries still fall below the minimum World Health Organization (WHO) TB treatment target success rate. There is conflicting evidence about whether concentrations of anti-tuberculosis drugs given at standard doses have an effect on treatment outcomes. The current data correlating anti-TB drug concentrations and treatment outcome is limited. This article summarized the existing literature and their utility in evaluating the association between each anti-TB drug's concentrations using current target concentrations and treatment outcomes in patients with pulmonary tuberculosis receiving standard WHO-recommended dosing.",
keywords = "Anti-tuberculosis drugs, Concentrations, Treatment outcomes",
author = "Christine Sekaggya-Wiltshire and Mohammed Lamorde and Kiragga, {Agnes N.} and Dooley, {Kelly E.} and Kamya, {Moses R.} and Andrew Kambugu and Jan Fehr and Manabe, {Yukari C.} and Barbara Castelnuovo",
note = "Funding Information: This work was supported by the National Institutes of Health Office of the Director , Fogarty International Center , Office of AIDS Research , National Cancer Center , National Heart, Blood, and Lung Institute , and the NIH Office of Research for Women's Health through the Fogarty Global Health Fellows Program Consortium comprised of the University of North Carolina, John Hopkins, Morehouse and Tulane ( R25TW009340 ). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",
year = "2018",
month = jan,
doi = "10.1016/j.tube.2017.11.004",
language = "English (US)",
volume = "108",
pages = "77--82",
journal = "Tuberculosis",
issn = "1472-9792",
publisher = "Churchill Livingstone",
}