The use of genetically modified embryonic stem cells to generate transgenic mice

M. V. Pryzhkova; I. R. Zakeeva; A. V. Kibardin; G. P. Georgier; S. L. Kiselev

The use of genetically modified embryonic stem cells to generate transgenic mice

M. V. Pryzhkova, I. R. Zakeeva, A. V. Kibardin, G. P. Georgier, S. L. Kiselev

Research output: Contribution to journal › Article › peer-review

Abstract

Targeted genetic modification of embryonic stem cells (ESC) was used to obtain nondifferentiated cell clones containing the foreign genetic material in the genome. It was demonstrated that transgenic animals may be obtained by ESC injection in preimplantation embryos and subsequent transplantation of the embryos into a recipient female. Using this method, we constructed chimeric animals with a modified genome.

Original language	English (US)
Pages (from-to)	311-315
Number of pages	5
Journal	Genetika
Volume	40
Issue number	3
State	Published - Dec 1 2004
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

Cite this

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title = "The use of genetically modified embryonic stem cells to generate transgenic mice",

abstract = "Targeted genetic modification of embryonic stem cells (ESC) was used to obtain nondifferentiated cell clones containing the foreign genetic material in the genome. It was demonstrated that transgenic animals may be obtained by ESC injection in preimplantation embryos and subsequent transplantation of the embryos into a recipient female. Using this method, we constructed chimeric animals with a modified genome.",

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AU - Zakeeva, I. R.

AU - Kibardin, A. V.

AU - Georgier, G. P.

AU - Kiselev, S. L.

PY - 2004/12/1

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The use of genetically modified embryonic stem cells to generate transgenic mice

Abstract

ASJC Scopus subject areas

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