TY - JOUR
T1 - The unusual coordination abilities of the peptides with βxaaHisGlyHis sequence. the influence of structural modification of the peptide chain on the copper(ii) binding
AU - Brasuń, Justyna
AU - Czapor, Hanna
AU - Matera-Witkiewicz, Agnieszka
AU - Kotynia, Aleksandra
AU - Sochacka, Aleksandra
AU - Cebrat, Marek
PY - 2010/7/28
Y1 - 2010/7/28
N2 - The coordination abilities of tetrapeptides containing β-amino acids towards Cu(ii) ions are presented. The studied tetrapeptides were: Ac-βAlaHisGlyHis, βAlaHisGlyHis, Ac-βAspHisGlyHis, βAspHisGlyHis, Ac-βAspHisGly-dHis and βAspHisGly-dHis. Thorough potentiometric titrations were carried out to establish the stoichiometry of the resulting metal-ligand complexes and the role of free -αCOO- side chain group in metal binding. The copper(ii) coordination mode of the complexes was investigated by performing detailed spectroscopic analyses (UV-Vis, EPR, CD) in strict correlation with potentiometric measurements.
AB - The coordination abilities of tetrapeptides containing β-amino acids towards Cu(ii) ions are presented. The studied tetrapeptides were: Ac-βAlaHisGlyHis, βAlaHisGlyHis, Ac-βAspHisGlyHis, βAspHisGlyHis, Ac-βAspHisGly-dHis and βAspHisGly-dHis. Thorough potentiometric titrations were carried out to establish the stoichiometry of the resulting metal-ligand complexes and the role of free -αCOO- side chain group in metal binding. The copper(ii) coordination mode of the complexes was investigated by performing detailed spectroscopic analyses (UV-Vis, EPR, CD) in strict correlation with potentiometric measurements.
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U2 - 10.1039/b923371g
DO - 10.1039/b923371g
M3 - Article
C2 - 20539897
AN - SCOPUS:77954585864
SN - 1477-9226
VL - 39
SP - 6518
EP - 6523
JO - Dalton Transactions
JF - Dalton Transactions
IS - 28
ER -