The unexplained survival of cells in oral cancer: What is the role of p53?

Donna A. Whyte, Claire E. Broton, Edward J. Shillitoe

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


In normal oral epithelium the cells divide, mature, differentiate, and die. This sequence is not normally followed in oral cancer. Instead, the death of the cells is somehow prevented, although the pathways toward cell death in normal oral epithelium and the defects in oral cancer are not well defined. However, several components in the system have been identified, and information on their interactions is becoming available. This review summarizes the evidence for cell death being due to apoptosis and the central role of the p53 gene product in its regulation. Areas for future research are also identified.

Original languageEnglish (US)
Pages (from-to)125-133
Number of pages9
JournalJournal of Oral Pathology and Medicine
Issue number3
StatePublished - 2002
Externally publishedYes


  • Apoptosis
  • Oral cancer
  • P53

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics


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