The treatment of osteoarthritis of the knee with pulsed electrical stimulation

T. M. Zizic, K. C. Hoffman, P. A. Holt, D. S. Hungerford, J. R. O'Dell, M. A. Jacobs, C. G. Lewis, C. L. Deal, J. R. Caldwell, J. G. Cholewczynski, S. M. Free

Research output: Contribution to journalArticlepeer-review

114 Scopus citations


Objective. The safety and effectiveness of pulsed electrical stimulation was evaluated for the treatment of osteoarthritis (OA) of the knee. Methods. A multicenter, double blind, randomized, placebo controlled trial that enrolled 78 patients with OA of the knee incorporated 3 primary efficacy variables of patients' pain, patients' function, and physician global evaluation of patients' condition, and 6 secondary variables that included duration of morning stiffness, range of motion, knee tenderness, joint swelling, joint circumference, and walking time. Measurements were recorded at baseline and during the 4 week treatment period. Results. Patients treated with the active devices showed significantly greater improvement than the placebo group for all primary efficacy variables in comparisons of mean change from baseline to the end of treatment (p <0.05). Improvement of ≥50% from baseline was demonstrated in at least one primary efficacy variable in 50% of the active device group, in 2 variables in 32%, and in all 3 variables in 24%. In the placebo group improvement of ≥ 50% occurred in 36% for one, 6% for 2, and 6% for 3 variables. Mean morning stiffness decreased 20 min in the active device group and increased 2 min in the placebo group (p <0.05). No statistically significant differences were observed for tenderness, swelling, or walking time. Conclusion. The improvements in clinical measures for pain and function found in this study suggest that pulsed electrical stimulation is effective for treating OA of the knee. Studies for longterm effects are warranted.

Original languageEnglish (US)
Pages (from-to)1757-1761
Number of pages5
JournalJournal of Rheumatology
Issue number9
StatePublished - 1995
Externally publishedYes



ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology


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