@article{ba828a4fa7964601a75942c72298c3fc,
title = "The transcriptional modulator HMGA2 promotes stemness and tumorigenicity in glioblastoma",
abstract = "Glioblastoma (GBM) contains a population of stem-like cells that promote tumor invasion and resistance to therapy. Identifying and targeting stem cell factors in GBM may lead to the development of more effective therapies. High Mobility Group AT-hook 2 (HMGA2) is a transcriptional modulator that mediates motility and self-renewal in normal and cancer stem cells. We identified increased expression of HMGA2 in the majority of primary human GBM tumors and cell lines compared to normal brain. Additionally, HMGA2 expression was increased in CD133+ GBM neurosphere cells compared to CD133- cells. Targeting HMGA2 with lentiviral short hairpin RNA (shRNA) led to decreased GBM stemness, invasion, and tumorigenicity. Ectopic expression of HMGA2 in GBM cell lines promoted stemness, invasion, and tumorigenicity. Our data suggests that targeting HMGA2 in GBM may be therapeutically beneficial.",
keywords = "Clonogenicity, GSC, Glioma, HMGI-C, Motility",
author = "Harpreet Kaur and Ali, {Sabeen Zulfiqar} and Lauren Huey and Marianne H{\"u}tt-Cabezas and Isabella Taylor and Mao, {Xing gang} and Melanie Weingart and Qian Chu and Rodriguez, {Fausto J.} and Eberhart, {Charles G.} and Raabe, {Eric H.}",
note = "Funding Information: We thank Dr. Angelo Vescovi for sharing HSR-GBM1 cells and Dr. Gregory Riggins for kindly providing us with JHH520 cells. We also thank Antoinette Price and Jessica Hicks for assistance with immunohistochemistry. This work is dedicated to the memory of Haley House, whose family's benefaction supports research in the Raabe laboratory. This work was supported by NCI Core Grant to the Johns Hopkins SKCCC P30 CA006973; The Children's Brain Tumor Foundation; The Giant Food Pediatric Cancer Research Fund; a gift from the House family in memory of Haley House. E.H.R. is a St. Baldrick's Scholar. Funding Information: NCI Core Grant to the Johns Hopkins SKCCC P30 CA006973 ; The Children's Brain Tumor Foundation ; The Giant Food Pediatric Cancer Research Fund ; a gift from the House family in memory of Haley House. E.H.R. is a St. Baldrick's Scholar. Publisher Copyright: {\textcopyright} 2016 Elsevier Ireland Ltd.",
year = "2016",
month = jul,
day = "10",
doi = "10.1016/j.canlet.2016.04.020",
language = "English (US)",
volume = "377",
pages = "55--64",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",
}