@article{5b397babc077443db108fb3494adb0c6,
title = "The telomere syndromes.",
abstract = "There has been mounting evidence of a causal role for telomere dysfunction in a number of degenerative disorders. Their manifestations encompass common disease states such as idiopathic pulmonary fibrosis and bone marrow failure. Although these disorders seem to be clinically diverse, collectively they comprise a single syndrome spectrum defined by the short telomere defect. Here we review the manifestations and unique genetics of telomere syndromes. We also discuss their underlying molecular mechanisms and significance for understanding common age-related disease processes.",
author = "Mary Armanios and Blackburn, {Elizabeth H.}",
note = "Funding Information: Much of the basic biology that is relevant to disease and that is discussed in this Review has been studied in a number of model organisms, and we acknowledge that owing to space limitations we could not reference that important work comprehensively. We are grateful to several colleagues and laboratory members for helpful discussions and comments on the manuscript. M.A. acknowledges research support from the US National Institutes of Health Heart, Lung and Blood Institute (NHLBI), the US National Cancer Institute (NCI) and the Maryland Stem Cell and Flight Attendants Medical Research Foundations. E.H.B. acknowledges support from the US National Institute of General Medical Sciences (NIGMS) and the NCI.",
year = "2012",
month = oct,
doi = "10.1038/nrg3246",
language = "English (US)",
volume = "13",
pages = "693--704",
journal = "Nature reviews. Genetics",
issn = "1471-0056",
publisher = "Nature Research",
number = "10",
}