The systems biology of glycosylation

Michael P. Murrell, Kevin J. Yarema, Andre Levchenko

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations


Glycosylation can have a profound influence on the function of a variety of eukaryotic cells. In particular, it can affect signal transduction and cell-cell communication properties and thus shape critical cell decisions, including the regulation of differentiation and apoptosis. Regulation of glycosylation has multiple layers of complexity, both structural and functional, which make its experimental and theoretical analysis difficult to perform and interpret. Novel research methodologies provided by systems biology can help to address many outstanding issues and integrate glycosylation with other metabolic and cell regulation processes. Here we review the toolbox available for biochemical systems analysis of glycosylation.

Original languageEnglish (US)
Pages (from-to)1334-1347
Number of pages14
Issue number10
StatePublished - Oct 4 2004
Externally publishedYes


  • Biochemical pathways
  • Carbohydrates
  • Glycosylation
  • Metabolic flux
  • Systems biology

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry


Dive into the research topics of 'The systems biology of glycosylation'. Together they form a unique fingerprint.

Cite this