The synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones as novel protein kinase C modulators

L. Zhao; L. Qiao; S. B. Rong; A. P. Kozikowski

doi:10.1016/S0040-4039(00)01561-6

The synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones as novel protein kinase C modulators

L. Zhao
, L. Qiao
, S. B. Rong
, A. P. Kozikowski

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The total synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones from D-serine methyl ester is described. The key step in the synthesis is a reductive amination reaction which is brought about using titanium(IV) isopropoxide and sodium cyanoborohydride, followed by the cyclization to urea using triphosgene after deprotection. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	8711-8715
Number of pages	5
Journal	Tetrahedron Letters
Volume	41
Issue number	45
DOIs	https://doi.org/10.1016/S0040-4039(00)01561-6
State	Published - Nov 4 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "The synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones as novel protein kinase C modulators",

abstract = "The total synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones from D-serine methyl ester is described. The key step in the synthesis is a reductive amination reaction which is brought about using titanium(IV) isopropoxide and sodium cyanoborohydride, followed by the cyclization to urea using triphosgene after deprotection. (C) 2000 Elsevier Science Ltd.",

author = "L. Zhao and L. Qiao and Rong, \{S. B.\} and Kozikowski, \{A. P.\}",

note = "Funding Information: This work was supported by the Department of Defense (DMAD 17-93-V-3018) and NIH grant CA79601. ",

year = "2000",

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doi = "10.1016/S0040-4039(00)01561-6",

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T1 - The synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones as novel protein kinase C modulators

AU - Zhao, L.

AU - Qiao, L.

AU - Rong, S. B.

AU - Kozikowski, A. P.

N1 - Funding Information: This work was supported by the Department of Defense (DMAD 17-93-V-3018) and NIH grant CA79601.

PY - 2000/11/4

Y1 - 2000/11/4

N2 - The total synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones from D-serine methyl ester is described. The key step in the synthesis is a reductive amination reaction which is brought about using titanium(IV) isopropoxide and sodium cyanoborohydride, followed by the cyclization to urea using triphosgene after deprotection. (C) 2000 Elsevier Science Ltd.

AB - The total synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones from D-serine methyl ester is described. The key step in the synthesis is a reductive amination reaction which is brought about using titanium(IV) isopropoxide and sodium cyanoborohydride, followed by the cyclization to urea using triphosgene after deprotection. (C) 2000 Elsevier Science Ltd.

UR - https://www.scopus.com/pages/publications/0034605809

UR - https://www.scopus.com/pages/publications/0034605809#tab=citedBy

U2 - 10.1016/S0040-4039(00)01561-6

DO - 10.1016/S0040-4039(00)01561-6

M3 - Article

AN - SCOPUS:0034605809

SN - 0040-4039

VL - 41

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 45

ER -

The synthesis of substituted (4S)-4-(hydroxymethyl)imidazolidin-2-ones as novel protein kinase C modulators

Abstract

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