The surgical management of goiter: Part II. Surgical treatment and results

Gregory W. Randolph, Jennifer J. Shin, Hermes C. Grillo, Doug Mathisen, Mark R. Katlic, Dipti Kamani, David Zurakowski

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Objectives/Hypothesis: Surgery for goiter embodies a unique challenge. Our objective is to provide a comprehensive analysis of cervical and substernal goiter data in two paired articles. This second article focuses on surgical management. The following null hypotheses regarding goiter excision have been tested: 1) there are no goiter-associated risk factors for difficult intubation; 2) there are no predictive risk factors for recurrent laryngeal nerve injury (RLN) or postoperative hypocalcemia; 3) there is no difference in RLN injury with neural monitoring versus without. Study Design: A retrospective review of 200 consecutive thyroidectomies meeting inclusion/exclusion criteria for cervical or substernal goiter. Results: Temporary RLN paralysis occurred in 1.8% of nerves at risk and was significantly lower with recurrent laryngeal nerve monitoring than without. Permanent hypoparathyroidism occurred in 3% overall. Bilateral cervical goiter emerged as a definitive risk factor for difficult intubation (P =.05, univariate), recurrent laryngeal nerve injury (P =.002), and postoperative hypocalcemia (P =.001). Female patients (P =.04) or patients with positive family history (P =.01) were more likely to need repeat surgery. There were no cases of tracheomalacia, and sternotomy was required in 1%. Conclusions: In this series of patients with extensive goiter, primary and revision surgery were associated with low rate of complications. Surgical complications were associated with bilateral and large goiters suggesting increased caution in these patients. Laryngoscope, 2011

Original languageEnglish (US)
Pages (from-to)68-76
Number of pages9
Issue number1
StatePublished - Jan 2011
Externally publishedYes


  • Goiter
  • Level of Evidence: 3b.
  • substernal goiter
  • thyroid surgery, thyroid disease management, thyroid neoplasm, recurrent laryngeal nerve injury, thyroidectomy
  • thyromegaly

ASJC Scopus subject areas

  • Otorhinolaryngology


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