@inproceedings{27a33ef7b52d45ccb3c7a6f24a004b4d,
title = "The study of photoacoustic imaging without nanoparticles as a contrast agent for anti-body drug monitoring",
abstract = "As an emerging hybrid Imaging, Photoacoustic became a powerful tool that can scan disease at the deeper site in tissue and monitor of drug delivery in vivo. PAI system used nano-particle as contrast agent to enhance the PA signal in deeper site in tissue. So this makes that PAIs application have some limitation for monitoring of all kinds of anti-body drug, because of various anti-bodys absorption excitation. In this study, we designed a PAI system with a tunable pulse OPO laser (from 450∼700nm excitation wavelength) to show the optimal wavelength for monitoring of the antibody drug; doxorubicin having peak absorption at near 500nm excitation without any nano-particle combine. We made a gelatin phantoms having 4 different concentration doxorubicin as an anti-body drug; Doxorubicin concentration were in- 0mg/ml, 0.5mg/ml, 1mg/ml, and 2mg/ml. We found that 500nm is optimization wavelength to produce PA peak signal and PAI can be tool to monitor of anti-body drug without contrast agent.",
keywords = "absorption, anti-body drug, contrast agent, doxorubicin, drug monitoring, Photoacoustic imaging",
author = "Han, {Seung Hee} and Jeeun Kang and Brian Wilson and Song, {Tai Kyong} and Kim, {Young Il}",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only. {\textcopyright} 2015 SPIE.; Medical Imaging 2015: Ultrasonic Imaging and Tomography ; Conference date: 22-02-2015 Through 23-02-2015",
year = "2015",
doi = "10.1117/12.2082439",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Neb Duric and Bosch, {Johan G.}",
booktitle = "Medical Imaging 2015",
}