The state of melanoma: challenges and opportunities

Glenn Merlino, Meenhard Herlyn, David E. Fisher, Boris C. Bastian, Keith T. Flaherty, Michael A. Davies, Jennifer A. Wargo, Clara Curiel-Lewandrowski, Michael J. Weber, Sancy A. Leachman, Maria S. Soengas, Martin McMahon, J. William Harbour, Susan M. Swetter, Andrew E. Aplin, Michael B. Atkins, Marcus W. Bosenberg, Reinhard Dummer, Jeffrey E. Gershenwald, Allan C. HalpernDorothee Herlyn, Giorgos C. Karakousis, John M. Kirkwood, Michael Krauthammer, Roger S. Lo, Georgina V. Long, Grant McArthur, Antoni Ribas, Lynn Schuchter, Jeffrey A. Sosman, Keiran S. Smalley, Patricia Steeg, Nancy E. Thomas, Hensin Tsao, Thomas Tueting, Ashani Weeraratna, George Xu, Randy Lomax, Alison Martin, Steve Silverstein, Tim Turnham, Ze'ev A. Ronai

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


The Melanoma Research Foundation (MRF) has charted a comprehensive assessment of the current state of melanoma research and care. Intensive discussions among members of the MRF Scientific Advisory Council and Breakthrough Consortium, a group that included clinicians and scientists, focused on four thematic areas – diagnosis/early detection, prevention, tumor cell dormancy (including metastasis), and therapy (response and resistance). These discussions extended over the course of 2015 and culminated at the Society of Melanoma Research 2015 International Congress in November. Each of the four groups has outlined their thoughts as per the current status, challenges, and opportunities in the four respective areas. The current state and immediate and long-term needs of the melanoma field, from basic research to clinical management, are presented in the following report.

Original languageEnglish (US)
Pages (from-to)404-416
Number of pages13
JournalPigment Cell and Melanoma Research
Issue number4
StatePublished - Jul 1 2016
Externally publishedYes


  • dormancy
  • early diagnosis
  • melanoma
  • metastasis
  • prevention
  • therapy

ASJC Scopus subject areas

  • Oncology
  • General Biochemistry, Genetics and Molecular Biology
  • Dermatology


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