The spermicide nonoxynol-9 does not inactivate papillomavirus

Paul L. Hermonat, Richard W. Daniel, Keerti V. Shah

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Vaginal spermicides are effective contraceptives, and are also capable of inactivating many sexually transmitted pathogens by their detergent effect on bacterial cell membranes and viral envelopes. A 5% concentration of nonoxynol-9, the most frequently used active ingredient of spermicides, was tested for its ability to reduce the transforming activity of bovine papilloma-virus type 1 (BPV-1), and the infectivity of BK virus (BKV) and cytomegalovirus (CMV). Nonoxynol-9 markedly reduced the infectivity of CMV, an enveloped virus, but did not significantly affect the activity of the nonenveloped viruses BPV-1 and BKV. Papillomavirus infections are strongly implicated in the etiology of cervical cancer. The reported protective effect of vaginal spermicides against cervical cancer is very likely not mediated by direct inactivation of papillomaviruses by the spermicide.

Original languageEnglish (US)
Pages (from-to)203-205
Number of pages3
JournalSexually transmitted diseases
Issue number4
StatePublished - 1992

ASJC Scopus subject areas

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Microbiology (medical)
  • Infectious Diseases


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