The sirtuin family's role in aging and age-associated pathologies

Jessica A. Hall; John E. Dominy; Yoonjin Lee; Pere Puigserver

doi:10.1172/JCI64094

The sirtuin family's role in aging and age-associated pathologies

Jessica A. Hall, John E. Dominy, Yoonjin Lee, Pere Puigserver

Research output: Contribution to journal › Article › peer-review

136 Scopus citations

Abstract

The 7 mammalian sirtuin proteins compose a protective cavalry of enzymes that can be invoked by cells to aid in the defense against a vast array of stressors. The pathologies associated with aging, such as metabolic syndrome, neurodegeneration, and cancer, are either caused by or exacerbated by a lifetime of chronic stress. As such, the activation of sirtuin proteins could provide a therapeutic approach to buffer against chronic stress and ameliorate age-related decline. Here we review experimental evidence both for and against this proposal, as well as the implications that isoform-specific sirtuin activation may have for healthy aging in humans.

Original language	English (US)
Pages (from-to)	973-979
Number of pages	7
Journal	Journal of Clinical Investigation
Volume	123
Issue number	3
DOIs	https://doi.org/10.1172/JCI64094
State	Published - Mar 1 2013
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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10.1172/JCI64094

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The sirtuin family's role in aging and age-associated pathologies

Abstract

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