TY - JOUR
T1 - THE SCIENCE AND PRACTICE OF ERECTION PHYSIOLOGY
T2 - STORY OF A REVOLUTIONARY GASEOUS MOLECULE
AU - Burnett, Arthur L.
PY - 2019
Y1 - 2019
N2 - The field of sexual medicine, in reference to the science of the sexual response and the clinical management of sexual dysfunctions, has evolved remarkably in the last 25 years. Erection biology has been central in driving this progress and is measured considerably by the discovery, study, and clinical translation of a simple gaseous molecule, nitric oxide, which is operative in the penis. Nitric oxide functions extraordinarily as a neurotransmitter and molecular signal transducer. It is now well understood to be the principal molecular mediator of penile erection and to be a critical element involved in dysregulatory mechanisms of erection disorders ranging from erectile dysfunction to priapism. It is most familiarly associated with the scientific development of oral medications for treating erectile dysfunction, which has modernized the clinical management of this condition.
AB - The field of sexual medicine, in reference to the science of the sexual response and the clinical management of sexual dysfunctions, has evolved remarkably in the last 25 years. Erection biology has been central in driving this progress and is measured considerably by the discovery, study, and clinical translation of a simple gaseous molecule, nitric oxide, which is operative in the penis. Nitric oxide functions extraordinarily as a neurotransmitter and molecular signal transducer. It is now well understood to be the principal molecular mediator of penile erection and to be a critical element involved in dysregulatory mechanisms of erection disorders ranging from erectile dysfunction to priapism. It is most familiarly associated with the scientific development of oral medications for treating erectile dysfunction, which has modernized the clinical management of this condition.
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M3 - Review article
C2 - 31516164
AN - SCOPUS:85072143061
SN - 0065-7778
VL - 130
SP - 51
EP - 59
JO - Transactions of the American Clinical and Climatological Association
JF - Transactions of the American Clinical and Climatological Association
ER -