The role of vascular cell adhesion molecule-1 in tumor immune evasion

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77 Scopus citations


Tumor immune escape is a critical trait of cancer but the mechanisms involved have yet to fully emerge. One recent study has shown that tumor cells can escape T-cell immunity by overexpressing the endothelial cell adhesion molecule vascular cell adhesion molecule-1 (VCAM-1), which normally mediates leukocyte extravasion to sites of tissue inflammation. Renal cell carcinoma (RCC) was identified as one tumor type where VCAM-1 is commonly highly overexpressed. Together, our findings suggest that RCCs might exploit VCAM-1 overexpression for immune escape.

Original languageEnglish (US)
Pages (from-to)6003-6006
Number of pages4
JournalCancer Research
Issue number13
StatePublished - Jul 1 2007

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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