The role of vagal afferent nerves in chronic obstructive pulmonary disease

Bradley J. Undem, Marian Kollarik

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


Circumstantial evidence supports the hypothesis that the vagal nervous system is dysregulated in chronic obstructive pulmonary disease. This dysregulation can lead to an increased sensitivity of the cough reflex such that the coughing becomes, at times, "nonproductive" or inappropriate. Vagal dysregulation can also lead to an increase in the activity of the parasympathetic reflex control of the airways, which contributes to greater mucus secretion and bronchial smooth muscle contraction. Indirect evidence indicates that lung disease is accompanied by substantive changes to the entire reflex pathways, including enhanced activity of the primary afferent nerves, increases in synaptic efficacy at secondary nerves in the central nervous system, and changes in the autonomic nerve pathways. Drugs aimed at normalizing neuronal activity may, therefore, be beneficial in chronic obstructive pulmonary disease.

Original languageEnglish (US)
Pages (from-to)355-360
Number of pages6
JournalProceedings of the American Thoracic Society
Issue number4
StatePublished - 2005


  • Bronchopulmonary C-fibers
  • Nociceptors
  • Stretch-sensitive mechanosensors
  • Vagal dysregulation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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