The role of the microbiology laboratory in antimicrobial stewardship programs

Edina Avdic; Karen C. Carroll

doi:10.1016/j.idc.2014.01.002

The role of the microbiology laboratory in antimicrobial stewardship programs

Edina Avdic, Karen C. Carroll

School of Medicine

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

One of the impediments to the success of antimicrobial stewardship is the lack of availability of rapid and sensitive laboratory tests. The last decade has seen an explosion in new technologies that permit, in less than 4hours, the identification of organisms and their resistance markers. In addition, the use of biomarkers has been explored in algorithms to distinguish infections that require antimicrobial agents. Clinical microbiology laboratories also contribute to the success of stewardship programs through compilation of aggregate antimicrobial susceptibility data. This article reviews rapid diagnostics, the use of biomarkers, and antibiogram development to antimicrobial stewardship activities and the subsequent impact on patient outcomes.

Original language	English (US)
Pages (from-to)	215-235
Number of pages	21
Journal	Infectious disease clinics of North America
Volume	28
Issue number	2
DOIs	https://doi.org/10.1016/j.idc.2014.01.002
State	Published - Jun 2014

Keywords

Antibiogram
Antimicrobial stewardship
Microbiology laboratory
Procalcitonin
Rapid diagnostics

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1016/j.idc.2014.01.002

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abstract = "One of the impediments to the success of antimicrobial stewardship is the lack of availability of rapid and sensitive laboratory tests. The last decade has seen an explosion in new technologies that permit, in less than 4hours, the identification of organisms and their resistance markers. In addition, the use of biomarkers has been explored in algorithms to distinguish infections that require antimicrobial agents. Clinical microbiology laboratories also contribute to the success of stewardship programs through compilation of aggregate antimicrobial susceptibility data. This article reviews rapid diagnostics, the use of biomarkers, and antibiogram development to antimicrobial stewardship activities and the subsequent impact on patient outcomes.",

keywords = "Antibiogram, Antimicrobial stewardship, Microbiology laboratory, Procalcitonin, Rapid diagnostics",

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note = "Funding Information: Disclosures: Dr E. Avdic does not have disclosures. Dr K.C. Carroll has received research funding from BioFire Diagnostics, Inc , Nanosphere, Inc , and Curetis, Inc . She is on the scientific advisory boards of Quidel Biosciences, Inc and NanoMR, Inc. ",

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AB - One of the impediments to the success of antimicrobial stewardship is the lack of availability of rapid and sensitive laboratory tests. The last decade has seen an explosion in new technologies that permit, in less than 4hours, the identification of organisms and their resistance markers. In addition, the use of biomarkers has been explored in algorithms to distinguish infections that require antimicrobial agents. Clinical microbiology laboratories also contribute to the success of stewardship programs through compilation of aggregate antimicrobial susceptibility data. This article reviews rapid diagnostics, the use of biomarkers, and antibiogram development to antimicrobial stewardship activities and the subsequent impact on patient outcomes.

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KW - Procalcitonin

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The role of the microbiology laboratory in antimicrobial stewardship programs

Abstract

Keywords

ASJC Scopus subject areas

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