@article{f5f8b2f1cbed4077aab0d889d4f7b9a3,
title = "The role of postmortem studies in Pneumonia etiology research",
abstract = "The diagnosis of etiology in severe pneumonia remains a challenging area. Postmortem lung tissue potentially increases the sensitivity of investigations for identification of causative pathogens in fatal cases of pneumonia and can confirm antemortem microbiological diagnoses. Tissue sampling allows assessment of histological patterns of disease and ancillary immunohistochemical or molecular diagnostic techniques. It may also enhance the recognition of noninfectious conditions that clinically simulate acute pneumonia. Biobanking of lung tissue or postmortem culture isolates offers opportunities for new pathogen discovery and research into host-pathogen interactions. The Pneumonia Etiology Research for Child Health study proposes a percutaneous needle biopsy approach to obtain postmortem samples, rather than a full open autopsy. This has the advantage of greater acceptability to relatives, but risks greater sampling error. Both approaches may be susceptible to microbiological contamination or pathogen degradation. However, previous autopsy studies have confirmed the value of histological examination in revealing unsuspected pathogens and influencing clinical guidelines for the diagnosis and treatment of future pneumonia cases.",
author = "Turner, {Gareth D.H.} and Charatdao Bunthi and Wonodi, {Chizoba B.} and Morpeth, {Susan C.} and Molyneux, {Catherine S.} and Zaki, {Sherif R.} and Levine, {Orin S.} and Murdoch, {David R.} and Scott, {J. Anthony G.}",
note = "Funding Information: Supplement sponsorship. This article was published as part of a supplement entitled {\textquoteleft}{\textquoteleft}Pneumonia Etiology Research for Child Health,{\textquoteright}{\textquoteright} sponsored by a grant from The Bill & Melinda Gates Foundation to the PERCH Project of Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. Potential conflicts of interest. All authors: No reported conflicts. Funding Information: Financial support. This work was supported by grant 48968 from The Bill & Melinda Gates Foundation to the International Vaccine Access Center, Department of International Health, Johns Hopkins Bloomberg School of Public Health. GDHT and CSM are funded by the Wellcome Trust of Great Britain. CBW, OSL and DRM are partly funded through the PERCH study and CBW and OSL through the John{\textquoteright}s Hopkins Bloomberg School of Public Health. SCM is funded by The Bill & Melinda Gates Foundation. CB is supported through the International Emerging Infections Diseases Program, and the Thailand Ministry of Public Health (MOPH)-U.S. Centers for Disease Control and Prevention (CDC) Collaboration. SRZ is supported through the CDC, Atlanta. JAGS is supported by a Senior Research Fellowship from The Wellcome Trust of Great Britain (No. 081835). This paper is published with the permission of the Director, KEMRI, Kenya.",
year = "2012",
month = apr,
day = "1",
doi = "10.1093/cid/cir1062",
language = "English (US)",
volume = "54",
pages = "S165--S171",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "SUPPL. 2",
}