The role of perivascular melanophage infiltrates in the conjunctiva in sympathetic ophthalmia

A. Jayaprakash Patil, Deepak P. Edward, Margaret Wong, Pars Ravichandran, Debra A. Goldstein

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Purpose: To report pathologic changes in the conjunctiva from the exciting eye in a case of sympathetic ophthalmia (SO). Methods: Report of clinical findings and conjunctival histopathology in a patient with SO. Results: A 50-year-old male developed SO, with unusual peribulbar conjunctival pigmentation in the inciting eye. Histological examination of the conjunctival biopsy revealed perivascular distribution of CD68+ melanophages that also expressed HLA-DR, suggesting that these macrophages may act as antigen-presenting cells. In addition, increased CD4+ and CD3 + lymphocytes were noted in the subconjunctival space when compared to specimens of normal conjunctiva and traumatic uveal prolapse without SO, suggesting T-cell recruitment. Conclusions: These pathologic findings suggest a possible mechanism by which local antigen processing by subconjunctival melanophages may play a role in the initiation of the complex cell-mediated response seen in SO.

Original languageEnglish (US)
Pages (from-to)186-191
Number of pages6
JournalOcular Immunology and Inflammation
Issue number3
StatePublished - Jun 2011
Externally publishedYes


  • CD68-positive cells
  • HLA-DR-positive macrophages
  • melanophages
  • sympathetic ophthalmia
  • uveitis

ASJC Scopus subject areas

  • Ophthalmology
  • Immunology and Allergy


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