TY - JOUR
T1 - The role of mood disorders in the progression of and recovery from alcohol and drug use problems
T2 - A latent transition analysis
AU - Crum, Rosa M.
AU - Green, Kerry M.
AU - Amin-Esmaeili, Masoumeh
AU - Susukida, Ryoko
AU - Mojtabai, Ramin
AU - Storr, Carla L.
AU - Riehm, Kira E.
AU - Young, Andrea S.
AU - Reboussin, Beth A.
N1 - Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/9/1
Y1 - 2022/9/1
N2 - Introduction: Longitudinal research assessing whether mood disorders predict substance use behaviors is limited. We extend our prior work evaluating transition patterns with alcohol use to assess patterns with alcohol and drug use problems. Method: Using National Epidemiologic Survey on Alcohol and Related Conditions prospective data, waves 1 and 2, we completed latent class analyses to empirically define classes of alcohol and drug problems from DSM disorder criteria. Latent transition analyses were used to assess associations of lifetime mood disorders at baseline with transitions across classes of alcohol and drug problems during follow-up. Results: A three-class model of alcohol and drug problems was identified (No problems, Alcohol Problems Only, and Alcohol and Drug Problems) for males and females. Females with mood disorders were over two times more likely to transition from No Problems, and Alcohol Problems Only at baseline to having both Alcohol and Drug Problems at follow-up relative to those without mood disorders (aOR=2.30, 95 % CI=1.31–4.05, p = 0.004, and aOR=2.64, CI=1.24–5.62, p = 0.011, respectively). Furthermore, females with mood disorders were significantly less likely to recover from baseline Alcohol and Drug Problems to Alcohol Problems Only at follow-up (aOR=0.35, CI=0.12–0.98, p = 0.047) relative to those without mood disorders. There were no significant findings for males. Discussion: Our study provides evidence that mood disorders impact transitions through classes of alcohol and drug problems among females. The findings emphasize the need for ongoing evaluation of substance use among those with mood conditions, and recognition and treatment of mood disorders among those recovering from substance use problems.
AB - Introduction: Longitudinal research assessing whether mood disorders predict substance use behaviors is limited. We extend our prior work evaluating transition patterns with alcohol use to assess patterns with alcohol and drug use problems. Method: Using National Epidemiologic Survey on Alcohol and Related Conditions prospective data, waves 1 and 2, we completed latent class analyses to empirically define classes of alcohol and drug problems from DSM disorder criteria. Latent transition analyses were used to assess associations of lifetime mood disorders at baseline with transitions across classes of alcohol and drug problems during follow-up. Results: A three-class model of alcohol and drug problems was identified (No problems, Alcohol Problems Only, and Alcohol and Drug Problems) for males and females. Females with mood disorders were over two times more likely to transition from No Problems, and Alcohol Problems Only at baseline to having both Alcohol and Drug Problems at follow-up relative to those without mood disorders (aOR=2.30, 95 % CI=1.31–4.05, p = 0.004, and aOR=2.64, CI=1.24–5.62, p = 0.011, respectively). Furthermore, females with mood disorders were significantly less likely to recover from baseline Alcohol and Drug Problems to Alcohol Problems Only at follow-up (aOR=0.35, CI=0.12–0.98, p = 0.047) relative to those without mood disorders. There were no significant findings for males. Discussion: Our study provides evidence that mood disorders impact transitions through classes of alcohol and drug problems among females. The findings emphasize the need for ongoing evaluation of substance use among those with mood conditions, and recognition and treatment of mood disorders among those recovering from substance use problems.
KW - Abuse
KW - Alcohol
KW - Dependence
KW - Depression
KW - Drug use
KW - Latent class analysis
KW - Latent transition analysis
KW - Mood disorders
KW - Substance use
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U2 - 10.1016/j.drugalcdep.2022.109566
DO - 10.1016/j.drugalcdep.2022.109566
M3 - Article
C2 - 35917762
AN - SCOPUS:85135201652
SN - 0376-8716
VL - 238
JO - Drug and alcohol dependence
JF - Drug and alcohol dependence
M1 - 109566
ER -