TY - JOUR
T1 - The role of microRNAs and long non-coding RNAs in the pathology, diagnosis, and management of melanoma
AU - Aftab, Muhammad Nauman
AU - Dinger, Marcel E.
AU - Perera, Ranjan J.
N1 - Funding Information:
This work was supported by National Institutes of Health Grants NCI 5P30CA030199 , CA165184 , and CA172847 to RJP. We also thank Ms. Debbie McFadden (Sanford-Burnham Medical Research Institute) for formatting the manuscript.
Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2014/12/15
Y1 - 2014/12/15
N2 - Melanoma is frequently lethal and its global incidence is steadily increasing. Despite the rapid development of different modes of targeted treatment, durable clinical responses remain elusive. A complete understanding of the molecular mechanisms that drive melanomagenesis is required, both genetic and epigenetic, in order to improve prevention, diagnosis, and treatment. There is increased appreciation of the role of microRNAs (miRNAs) in melanoma biology, including in proliferation, cell cycle, migration, invasion, and immune evasion. Data are also emerging on the role of long non-coding RNAs (lncRNAs), such as SPRY4-IT1, BANCR, and HOTAIR, in melanomagenesis. Here we review the data on the miRNAs and lncRNAs implicated in melanoma biology. An overview of these studies will be useful for providing insights into mechanisms of melanoma development and the miRNAs and lncRNAs that might be useful biomarkers or future therapeutic targets.
AB - Melanoma is frequently lethal and its global incidence is steadily increasing. Despite the rapid development of different modes of targeted treatment, durable clinical responses remain elusive. A complete understanding of the molecular mechanisms that drive melanomagenesis is required, both genetic and epigenetic, in order to improve prevention, diagnosis, and treatment. There is increased appreciation of the role of microRNAs (miRNAs) in melanoma biology, including in proliferation, cell cycle, migration, invasion, and immune evasion. Data are also emerging on the role of long non-coding RNAs (lncRNAs), such as SPRY4-IT1, BANCR, and HOTAIR, in melanomagenesis. Here we review the data on the miRNAs and lncRNAs implicated in melanoma biology. An overview of these studies will be useful for providing insights into mechanisms of melanoma development and the miRNAs and lncRNAs that might be useful biomarkers or future therapeutic targets.
KW - Melanoma
KW - MicroRNAs
KW - Molecular function
KW - Noncoding
KW - RNAs
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U2 - 10.1016/j.abb.2014.07.022
DO - 10.1016/j.abb.2014.07.022
M3 - Review article
C2 - 25065585
AN - SCOPUS:84908463126
SN - 0003-9861
VL - 563
SP - 60
EP - 70
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
ER -