TY - JOUR
T1 - The role of metabolic states in development and disease
AU - Sieber, Matthew H.
AU - Spradling, Allan C.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - During development, cells adopt distinct metabolic strategies to support growth, produce energy, and meet the demands of a mature tissue. Some of these metabolic states maintain a constrained program of nutrient utilization, while others providing metabolic flexibility as a means to couple developmental progression with nutrient availability. Here we discuss our understanding of metabolic programs, and how they support specific aspects of animal development. During phases of rapid proliferation a subset of metabolic programs provide the building blocks to support growth. During differentiation, metabolic programs shift to support the unique demands of each tissue. Finally, we discuss how a model system, such as Drosophila egg development, can provide a versatile platform to discover novel mechanisms controlling programmed shift in metabolism.
AB - During development, cells adopt distinct metabolic strategies to support growth, produce energy, and meet the demands of a mature tissue. Some of these metabolic states maintain a constrained program of nutrient utilization, while others providing metabolic flexibility as a means to couple developmental progression with nutrient availability. Here we discuss our understanding of metabolic programs, and how they support specific aspects of animal development. During phases of rapid proliferation a subset of metabolic programs provide the building blocks to support growth. During differentiation, metabolic programs shift to support the unique demands of each tissue. Finally, we discuss how a model system, such as Drosophila egg development, can provide a versatile platform to discover novel mechanisms controlling programmed shift in metabolism.
UR - http://www.scopus.com/inward/record.url?scp=85016070340&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85016070340&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2017.03.002
DO - 10.1016/j.gde.2017.03.002
M3 - Review article
C2 - 28347941
AN - SCOPUS:85016070340
SN - 0959-437X
VL - 45
SP - 58
EP - 68
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -