TY - JOUR
T1 - The role of major histocompatibility complex alleles in the susceptibility of Brazilian patients to develop the myogenic type of Graves' orbitopathy
AU - Akaishi, Patricia Mitiko Santello
AU - Cruz, Antonio Augusto Velasco
AU - Silva, Fabricio Leon Mascaro
AU - Rodrigues, Maria De Lourdes Veronesi
AU - Maciel, Lea Maria Zanini
AU - Donadi, Eduardo Antonio
PY - 2008/4/1
Y1 - 2008/4/1
N2 - Objective: To assess the frequency of the genetic markers HLA-DRB1 and DQB1 in patients with Graves' orbitopathy (GO) with and without extraocular muscle involvement. Design: The frequencies of class II HLA-DRB1 and DQB1 allele groups were determined for 81 Brazilian patients with GO and 161 normal subjects. The patients were divided into myogenic and nonmyogenic groups based on the clinical characteristics of the orbitopathy and quantitative computed tomography analysis of the extraocular muscle (EOM) dimensions. Main outcome: Compared to the frequency obtained for samples of normal subjects of the Brazilian population, HLA-DRB1*16 (pc = 0.008) was overrepresented in myogenic and HLA-DRB1*03 (pc = 0.02) in nonmyogenic patients. Conclusions: The association between the HLA-DRB1*16 and the myogenic subtype of GO suggests that EOM involvement in GO may be genetically predisposed.
AB - Objective: To assess the frequency of the genetic markers HLA-DRB1 and DQB1 in patients with Graves' orbitopathy (GO) with and without extraocular muscle involvement. Design: The frequencies of class II HLA-DRB1 and DQB1 allele groups were determined for 81 Brazilian patients with GO and 161 normal subjects. The patients were divided into myogenic and nonmyogenic groups based on the clinical characteristics of the orbitopathy and quantitative computed tomography analysis of the extraocular muscle (EOM) dimensions. Main outcome: Compared to the frequency obtained for samples of normal subjects of the Brazilian population, HLA-DRB1*16 (pc = 0.008) was overrepresented in myogenic and HLA-DRB1*03 (pc = 0.02) in nonmyogenic patients. Conclusions: The association between the HLA-DRB1*16 and the myogenic subtype of GO suggests that EOM involvement in GO may be genetically predisposed.
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U2 - 10.1089/thy.2007.0194
DO - 10.1089/thy.2007.0194
M3 - Article
C2 - 18352820
AN - SCOPUS:42049092362
SN - 1050-7256
VL - 18
SP - 443
EP - 447
JO - Thyroid
JF - Thyroid
IS - 4
ER -