TY - JOUR
T1 - The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function
T2 - From physiology to pathology
AU - Kiss, Mate
AU - Czimmerer, Zsolt
AU - Nagy, Laszlo
N1 - Funding Information:
M.K. is supported by the National Excellence Program ( TÁMOP 4.2.4.A/2-11-1-2012-0001 ) cofinanced by the European Union and Hungary. L.N. is supported by a grant from the Hungarian Scientific Research Fund ( OTKA K100196 ) and TÁMOP422_2012_0023 , which is implemented through the New Hungary Development Plan cofinanced by the European Social Fund and the European Regional Development Fund .
PY - 2013/8
Y1 - 2013/8
N2 - Nuclear receptors are ligand-activated transcription factors linking lipid signaling to the expression of the genome. There is increasing appreciation of the involvement of this receptor network in the metabolic programming of macrophages and dendritic cells (DCs), essential members of the innate immune system. In this review we focus on the role of retinoid X receptor, retinoic acid receptor, peroxisome proliferator-associated receptor γ, liver X receptor, and vitamin D receptor in shaping the immune and metabolic functions of macrophages and DCs. We also provide an overview of the contribution of macrophage- and DC-expressed nuclear receptors to various immunopathologic conditions, such as rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, asthma, and some others. We suggest that systematic analyses of the roles of these receptors and their activating lipid ligands in immunopathologies combined with complementary and focused translational and clinical research will be crucial for the development of new therapies using the many molecules available to target nuclear receptors.
AB - Nuclear receptors are ligand-activated transcription factors linking lipid signaling to the expression of the genome. There is increasing appreciation of the involvement of this receptor network in the metabolic programming of macrophages and dendritic cells (DCs), essential members of the innate immune system. In this review we focus on the role of retinoid X receptor, retinoic acid receptor, peroxisome proliferator-associated receptor γ, liver X receptor, and vitamin D receptor in shaping the immune and metabolic functions of macrophages and DCs. We also provide an overview of the contribution of macrophage- and DC-expressed nuclear receptors to various immunopathologic conditions, such as rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, asthma, and some others. We suggest that systematic analyses of the roles of these receptors and their activating lipid ligands in immunopathologies combined with complementary and focused translational and clinical research will be crucial for the development of new therapies using the many molecules available to target nuclear receptors.
KW - Macrophage
KW - dendritic cell
KW - inflammatory bowel disease
KW - lipid
KW - liver X receptor
KW - nuclear receptor
KW - peroxisome proliferator-associated receptor
KW - retinoic acid receptor
KW - retinoid X receptor
KW - rheumatoid arthritis
KW - systemic lupus erythematosus asthma
KW - vitamin D receptor
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U2 - 10.1016/j.jaci.2013.05.044
DO - 10.1016/j.jaci.2013.05.044
M3 - Review article
C2 - 23905916
AN - SCOPUS:84881135383
SN - 0091-6749
VL - 132
SP - 264
EP - 286
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 2
ER -