Abstract
Question: Which imaging techniques most accurately differentiate true tumor progression from pseudo-progression or treatment related changes in patients with previously diagnosed glioblastoma? Target population: These recommendations apply to adults with previously diagnosed glioblastoma who are suspected of experiencing progression of the neoplastic process. Recommendations Level II: Magnetic resonance imaging with and without gadolinium enhancement is recommended as the imaging surveillance method to detect the progression of previously diagnosed glioblastoma. Level II: Magnetic resonance spectroscopy is recommended as a diagnostic method to differentiate true tumor progression from treatment-related imaging changes or pseudo-progression in patients with suspected progressive glioblastoma. Level III: The routine use of positron emission tomography to identify progression of glioblastoma is not recommended. Level III: Single-photon emission computed tomography imaging is recommended as a diagnostic method to differentiate true tumor progression from treatment-related imaging changes or pseudo-progression in patients with suspected progressive glioblastoma.
Original language | English (US) |
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Pages (from-to) | 435-460 |
Number of pages | 26 |
Journal | Journal of neuro-oncology |
Volume | 118 |
Issue number | 3 |
DOIs | |
State | Published - Jul 2014 |
Keywords
- Glioblastoma
- Imaging
- Malignant glioma
- Practice guideline
- Progression
- Pseudo-progression
- Radiology
- Recurrence
- Systematic review
ASJC Scopus subject areas
- Oncology
- Neurology
- Clinical Neurology
- Cancer Research