The role of genetic modifiers, inflammation and CFTR in the pathogenesis of Cystic fibrosis related diabetes

Keyphrases

• Inflammation 100%
• Genetic Modifiers 100%
• Cystic Fibrosis-related Diabetes 100%
• Oxidative Stress 27%
• Insulin Secretion 18%
• Islet 18%
• Cell Dysfunction 18%
• CFTR Function 18%
• Islet Inflammation 18%
• Susceptibility Genes 9%
• Genome-wide Association Study 9%
• Multiple Mechanisms 9%
• Inflammatory Mediators 9%
• Insulin 9%
• Cell Loss 9%
• Type 2 Diabetes Mellitus (T2DM) 9%
• Cell Function 9%
• Diabetes Risk 9%
• Oxidative Inflammation 9%
• Cell-intrinsic 9%
• Cyclin-dependent Kinase Inhibitor 2A (CDKN2A) 9%
• Cell-extrinsic 9%
• Cell Defects 9%
• Cyclin-dependent Kinase 1 (CDK1) 9%
• Diabetes Type 1 9%
• CFTR mutations 9%
• Extrinsic Mechanism 9%
• Pancreatic Sufficiency 9%
• Diabetes Pathogenesis 9%
• Glucagon Secretion 9%
• TCF7L2 9%
• Insulin-like Growth Factor 2 mRNA-binding Protein 2 (IGF2BP2) 9%

Immunology and Microbiology

• Inflammation 100%
• Oxidative Stress 75%
• Insulin Release 50%
• Genome-Wide Association Study 25%
• Mediator 25%
• Cell Loss 25%
• Cell Function 25%
• Glucagon Release 25%
• Insulin 25%
• Susceptibility 25%