The role of endoscopic cryotherapy for treatment and palliation

Kristle Lee Lynch, Eun Ji Shin, Marcia Irene Canto

Research output: Chapter in Book/Report/Conference proceedingChapter


Cryotherapy, or cryoablation, refers to the application of extreme cold to tissue. Unlike other types of thermal treatments, cryotherapy leads to unwanted tissue destruction over a period of days, rather than in seconds, through a number of mechanisms. Endoscopic cryotherapy is a non-contact, technically simple ablative therapy using through-the-scope delivery of compressed gas or liquid cryogen. This chapter focuses on the basis, technique, and outcomes for the use of endoscopic cryotherapy in Barrett's esophagus and esophageal adenocarcinoma (EAC). While the published data are limited, these suggest high efficacy and good safety. Further technical development and research on optimal dosimetry for achieving consistent therapeutic response are needed.

Original languageEnglish (US)
Title of host publicationEsophageal Cancer and Barrett's Esophagus
Number of pages8
ISBN (Electronic)9781118655153
ISBN (Print)9781118655207
StatePublished - Dec 12 2015


  • Barrett's esophagus
  • Carbon dioxide cryotherapy
  • Cryoablation
  • Cryotherapy
  • Dysplasia
  • Endoscopy
  • Esophageal adenocarcinoma
  • Liquid nitrogen cryotherapy

ASJC Scopus subject areas

  • General Medicine


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