The role of calmodulin kinase II in myocardial physiology and disease

Luis F. Couchonnal; Mark E. Anderson

doi:10.1152/physiol.00043.2007

The role of calmodulin kinase II in myocardial physiology and disease

Luis F. Couchonnal, Mark E. Anderson

Research output: Contribution to journal › Review article › peer-review

100 Scopus citations

Abstract

The multifunctional Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) regulates a rich variety of downstream targets in heart. Ca ²⁺ homeostatic proteins are important CaMKII targets that support myocardial excitation-contraction coupling. Under stress conditions, excessive CaMKII activity promotes heart failure and arrhythmias, in part through actions at Ca²⁺ homeostatic proteins. Here, we briefly review the molecular and cellular physiology of CaMKII in myocardium.

Original language	English (US)
Pages (from-to)	151-159
Number of pages	9
Journal	Physiology
Volume	23
Issue number	3
DOIs	https://doi.org/10.1152/physiol.00043.2007
State	Published - Jun 2008
Externally published	Yes

ASJC Scopus subject areas

Physiology

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10.1152/physiol.00043.2007

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abstract = "The multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates a rich variety of downstream targets in heart. Ca 2+ homeostatic proteins are important CaMKII targets that support myocardial excitation-contraction coupling. Under stress conditions, excessive CaMKII activity promotes heart failure and arrhythmias, in part through actions at Ca2+ homeostatic proteins. Here, we briefly review the molecular and cellular physiology of CaMKII in myocardium.",

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AB - The multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates a rich variety of downstream targets in heart. Ca 2+ homeostatic proteins are important CaMKII targets that support myocardial excitation-contraction coupling. Under stress conditions, excessive CaMKII activity promotes heart failure and arrhythmias, in part through actions at Ca2+ homeostatic proteins. Here, we briefly review the molecular and cellular physiology of CaMKII in myocardium.

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The role of calmodulin kinase II in myocardial physiology and disease

Abstract

ASJC Scopus subject areas

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