The role of calcium in the regulation of apoptosis

David J. McConkey, Sten Orrenius

Research output: Contribution to journalReview articlepeer-review

218 Scopus citations


The recognition that apoptosis is regulated by an evolutionarily conserved set of polypeptides from the nematode Caenorhabditis elegans to humans suggests that a conserved set of biochemical mechanism(s) may also be involved in the response. Work from a number of independent laboratories suggests that alterations in cytosolic Ca2+ homeostasis represent one such candidate mechanism, and molecular targets for Ca2+ are now being identified. This review will summarize what is known about the role of Ca2+ in the regulation of apoptosis and discuss how Ca2+ might interact with some of the other biochemical signals implicated in cell death.

Original languageEnglish (US)
Pages (from-to)775-783
Number of pages9
JournalJournal of Leukocyte Biology
Issue number6
StatePublished - Jun 1996
Externally publishedYes


  • BCL-2
  • Endonuclease
  • Oxidative stress

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology


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