The role of calcium in the regulation of apoptosis

David J. McConkey, Sten Orrenius

Research output: Contribution to journalReview articlepeer-review

369 Scopus citations


Apoptosis (programmed cell death) has gained widespread attention due to its roles in a variety of physiological and pathological processes, yet precisely how apoptosis is regulated by external and internal cues remains unclear. Work from our laboratories and others has implicated alterations in intracellular Ca2+ in apoptosis, and more recent work has defined particular biochemical processes that are targeted by Ca2+ in apoptotic cells. This review will summarize the role of Ca2+ in apoptosis within the context of what is known about the core components of the effector machinery for apoptosis.

Original languageEnglish (US)
Pages (from-to)357-366
Number of pages10
JournalBiochemical and Biophysical Research Communications
Issue number2
StatePublished - Oct 20 1997
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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