The role of ATP-dependent machines in regulating genome topology

Glenn Hauk, James M. Berger

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


All cells must copy and express genes in accord with internal and external cues. The proper timing and response of such events relies on the active control of higher-order genomic organization. Cells use ATP-dependent molecular machines to alter the local and global topology of DNA so as to promote and counteract the persistent effects of transcription and replication. X-ray crystallography and electron microscopy, coupled with biochemical and single molecule methods are continuing to provide a wealth of mechanistic information on how DNA remodeling factors are employed to dynamically shape and organize the genome.

Original languageEnglish (US)
Pages (from-to)85-96
Number of pages12
JournalCurrent Opinion in Structural Biology
StatePublished - Feb 1 2016

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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