Abstract
All cells must copy and express genes in accord with internal and external cues. The proper timing and response of such events relies on the active control of higher-order genomic organization. Cells use ATP-dependent molecular machines to alter the local and global topology of DNA so as to promote and counteract the persistent effects of transcription and replication. X-ray crystallography and electron microscopy, coupled with biochemical and single molecule methods are continuing to provide a wealth of mechanistic information on how DNA remodeling factors are employed to dynamically shape and organize the genome.
Original language | English (US) |
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Pages (from-to) | 85-96 |
Number of pages | 12 |
Journal | Current Opinion in Structural Biology |
Volume | 36 |
DOIs | |
State | Published - Feb 1 2016 |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology