TY - JOUR
T1 - The role of adiponectin in reproduction
T2 - From polycystic ovary syndrome to assisted reproduction
AU - Michalakis, Konstantinos G.
AU - Segars, James H.
N1 - Funding Information:
Supported in part by the Program in Reproductive and Adult Endocrinology, National Institute of Child Health and Human Development, National Institutes of Health , Bethesda, Maryland.
PY - 2010/11
Y1 - 2010/11
N2 - Objective: To summarize the effects of the adipokine adiponectin on the reproductive endocrine system, from the hypothalamic-pituitary axis to the gonads and target tissues of the reproductive system. Design: A Medline computer search was performed to identify relevant articles. Setting: Research institution. Intervention(s): None. Result(s): Adiponectin is a hormone secreted by adipose tissue that acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other tissues. Adiponectin mediates its actions in the periphery mainly via two receptors, AdipoR1 and AdipoR2. Adiponectin receptors are present in many reproductive tissues, including the central nervous system, ovaries, oviduct, endometrium, and testes. Adiponectin influences gonadotropin release, normal pregnancy, and assisted reproduction outcomes. Conclusion(s): Adiponectin, a beneficial adipokine, represents a major link between obesity and reproduction. Higher levels of adiponectin are associated with improved menstrual function and better outcomes in assisted reproductive cycles.
AB - Objective: To summarize the effects of the adipokine adiponectin on the reproductive endocrine system, from the hypothalamic-pituitary axis to the gonads and target tissues of the reproductive system. Design: A Medline computer search was performed to identify relevant articles. Setting: Research institution. Intervention(s): None. Result(s): Adiponectin is a hormone secreted by adipose tissue that acts to reduce insulin resistance and atherogenic damage, but it also exerts actions in other tissues. Adiponectin mediates its actions in the periphery mainly via two receptors, AdipoR1 and AdipoR2. Adiponectin receptors are present in many reproductive tissues, including the central nervous system, ovaries, oviduct, endometrium, and testes. Adiponectin influences gonadotropin release, normal pregnancy, and assisted reproduction outcomes. Conclusion(s): Adiponectin, a beneficial adipokine, represents a major link between obesity and reproduction. Higher levels of adiponectin are associated with improved menstrual function and better outcomes in assisted reproductive cycles.
KW - Adiponectin
KW - PCOS
KW - assisted reproduction
KW - embryo development
KW - gonads
KW - hypothalamus
KW - pituitary
KW - polycystic ovary syndrome
KW - pregnancy
KW - reproduction
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U2 - 10.1016/j.fertnstert.2010.05.010
DO - 10.1016/j.fertnstert.2010.05.010
M3 - Article
C2 - 20561616
AN - SCOPUS:78049297430
SN - 0015-0282
VL - 94
SP - 1949
EP - 1957
JO - Fertility and sterility
JF - Fertility and sterility
IS - 6
ER -