The road to survival goes through PARG

David W. Koh; Valina L. Dawson; Ted M. Dawson

doi:10.4161/cc.4.3.1559

The road to survival goes through PARG

David W. Koh, Valina L. Dawson, Ted M. Dawson

School of Medicine

Research output: Contribution to journal › Short survey › peer-review

18 Scopus citations

Abstract

Unlike poly(ADP-ribose) polymerase-1 (PARP-1), poly(ADP-ribose) glycohydrolase (PARG) has long been a difficult protein to study. However, the complete absence of PARG activity was recently characterized in mice via disruption of the murine PARG gene. As expected, PARG is critical for the maintenance of steady-state poly(ADP-ribose) levels. But surprisingly, the disruption of PARG led to embryonic lethality and increased susceptibility to mild cell stress. Therefore, the protective role of PARG and its involvement in development indicate that these roads to viability go through PARG.

Original language	English (US)
Pages (from-to)	397-399
Number of pages	3
Journal	Cell Cycle
Volume	4
Issue number	3
DOIs	https://doi.org/10.4161/cc.4.3.1559
State	Published - Mar 2005

Keywords

Apoptosis
DNA damage
Embryo development
Gene targeting
PARP
Poly(ADP-ribose)

ASJC Scopus subject areas

Molecular Biology
Developmental Biology
Cell Biology

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title = "The road to survival goes through PARG",

abstract = "Unlike poly(ADP-ribose) polymerase-1 (PARP-1), poly(ADP-ribose) glycohydrolase (PARG) has long been a difficult protein to study. However, the complete absence of PARG activity was recently characterized in mice via disruption of the murine PARG gene. As expected, PARG is critical for the maintenance of steady-state poly(ADP-ribose) levels. But surprisingly, the disruption of PARG led to embryonic lethality and increased susceptibility to mild cell stress. Therefore, the protective role of PARG and its involvement in development indicate that these roads to viability go through PARG.",

keywords = "Apoptosis, DNA damage, Embryo development, Gene targeting, PARP, Poly(ADP-ribose)",

author = "Koh, {David W.} and Dawson, {Valina L.} and Dawson, {Ted M.}",

note = "Funding Information: This work was supported by grants from the NIH (NS39148), and the Christopher Reeve Paralysis Foundation (D.W.K.). T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "2005",

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doi = "10.4161/cc.4.3.1559",

language = "English (US)",

volume = "4",

pages = "397--399",

journal = "Cell Cycle",

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publisher = "Landes Bioscience",

number = "3",

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T1 - The road to survival goes through PARG

AU - Koh, David W.

AU - Dawson, Valina L.

AU - Dawson, Ted M.

N1 - Funding Information: This work was supported by grants from the NIH (NS39148), and the Christopher Reeve Paralysis Foundation (D.W.K.). T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 2005/3

Y1 - 2005/3

N2 - Unlike poly(ADP-ribose) polymerase-1 (PARP-1), poly(ADP-ribose) glycohydrolase (PARG) has long been a difficult protein to study. However, the complete absence of PARG activity was recently characterized in mice via disruption of the murine PARG gene. As expected, PARG is critical for the maintenance of steady-state poly(ADP-ribose) levels. But surprisingly, the disruption of PARG led to embryonic lethality and increased susceptibility to mild cell stress. Therefore, the protective role of PARG and its involvement in development indicate that these roads to viability go through PARG.

AB - Unlike poly(ADP-ribose) polymerase-1 (PARP-1), poly(ADP-ribose) glycohydrolase (PARG) has long been a difficult protein to study. However, the complete absence of PARG activity was recently characterized in mice via disruption of the murine PARG gene. As expected, PARG is critical for the maintenance of steady-state poly(ADP-ribose) levels. But surprisingly, the disruption of PARG led to embryonic lethality and increased susceptibility to mild cell stress. Therefore, the protective role of PARG and its involvement in development indicate that these roads to viability go through PARG.

KW - Apoptosis

KW - DNA damage

KW - Embryo development

KW - Gene targeting

KW - PARP

KW - Poly(ADP-ribose)

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VL - 4

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JO - Cell Cycle

JF - Cell Cycle

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The road to survival goes through PARG

Abstract

Keywords

ASJC Scopus subject areas

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