The rise of viperin: the emerging role of viperin in cancer progression

Alyssa G. Weinstein, Inês Godet, Daniele M. Gilkes

Research output: Contribution to journalReview articlepeer-review


Viperin, an IFN-regulated gene product, is known to inhibit fatty acid β-oxidation in the mitochondria, which enhances glycolysis and lipogenesis during viral infections. Yet, its role in altering the phenotype of cancer cells has not been established. In this issue of the JCI, Choi, Kim, and co-authors report on a role of viperin in regulating metabolic alterations in cancer cells. The authors showed a correlation between clinical outcomes and viperin expression levels in multiple cancer tissues and proposed that viperin expression was upregulated in the tumor microenvironment via the JAK/ STAT and PI3K/AKT/mTOR/HIF-1α pathways. Functionally, viperin increased lipogenesis and glycolysis in cancer cells by inhibiting fatty acid β-oxidation. Viperin expression also enhanced cancer stem cell properties, ultimately promoting tumor initiation in murine models. This study proposes a protumorigenic role for viperin and identifies HIF-1α as a transcription factor that increases viperin expression under serum starvation and hypoxia.

Original languageEnglish (US)
Article numbere165907
JournalJournal of Clinical Investigation
Issue number24
StatePublished - Dec 15 2022

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'The rise of viperin: the emerging role of viperin in cancer progression'. Together they form a unique fingerprint.

Cite this