Abstract
Background: Heart failure with preserved ejection fraction (HFpEF) is the predominant form of heart failure among the elderly and in women. However, there are few if any evidence-based therapeutic options for HFpEF. The chief complaint of HFpEF is reduced tolerance to physical exertion. Recent data revealed that 1 potential mechanism of exertional intolerance in HFpEF patients is inadequate chronotropic response. Although there is considerable evidence demonstrating the benefits of rate-adaptive pacing (RAP) provided from implantable cardiac devices in patients with an impaired chronotropic response, the effect of RAP in HFpEF is unknown. Methods and Results: The Restoration of Chronotropic CompEtence in Heart Failure PatientS with Normal Ejection FracTion (RESET) study is a prospective, multicenter, double-blind, randomized with stratification, study assessing the effect of RAP on peak oxygen consumption and quality of life. RAP therapy will be evaluated in a crossover paired fashion for each patient within each study stratum. Study strata are based on patient β-blocker usage at time of enrollment. The study is powered to assess the impact of pacing independently in both strata. Conclusions: The RESET study seeks to evaluate the potential benefit of RAP in patients with symptomatic mild to moderate HFpEF and chronotropic impairment. Study enrollment began in July 2008.
Original language | English (US) |
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Pages (from-to) | 17-24 |
Number of pages | 8 |
Journal | Journal of cardiac failure |
Volume | 16 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2010 |
Keywords
- Heart failure
- diastole
- ejection fraction
- heart rate
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine