@article{a0e93431921a44acb65e9c508388007c,
title = "The Renin-Angiotensin system and right ventricular structure and function: The MESA-Right ventricle study",
abstract = "The pulmonary vasculature is an important site of renin-angiotensin metabolism. While angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers (collectively AIABs) have a role in left ventricular (LV) disease, the impact of AIABs on right ventricular (RV) function is unknown. AIAB use was determined by medication inventory during the Multi-Ethnic Study of Atherosclerosis baseline examination. RV measures were obtained via cardiac magnetic resonance imaging. The relationship between AIAB use and RV measures was assessed using multivariable linear regression, stratified by race/ethnicity, and adjusted for multiple covariates. AIAB use was associated with lower RV mass (-0.7 g, 95% confidence interval [CI]-1.3 to-0.1, P=0.03) in African Americans (N=1012) after adjustment for multiple covariates including LV mass. Among Caucasians (N=1591), AIAB use was associated with larger RV end-diastolic volume (3.7 mL, 95% CI 0.7-6.8, P=0.02) after adjustment for LV volume. No significant associations were seen between AIAB use and other RV measures or in Hispanic or Chinese American participants. AIAB use was associated with RV morphology in a race-specific and LV-independent manner, suggesting the renin-angiotensin system may play a unique role in RV structure and function. The use of AIABs in those with RV dysfunction warrants further study.",
keywords = "Angiotensin II receptor blockers, Angiotensin-converting enzyme inhibitor, Epidemiology, Renin-angiotensin system, Right ventricle",
author = "Ventetuolo, {Corey E.} and Lima, {Joao A.C.} and Barr, {R. Graham} and Bristow, {Michael R.} and Emilia Bagiella and Harjit Chahal and Kizer, {Jorge R.} and Lederer, {David J.} and Bluemke, {David Alan} and Kawut, {Steven M.}",
note = "Funding Information: 1Departments of Medicine, and Health Services Policy & Practice, Alpert Medical School of Brown University, Providence, Rhode Island, USA, Departments of 2Medicine, 3Radiology, and 4Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA, 5Department of Medicine, College of Physicians and Surgeons, and the 6Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA, 7Department of Medicine, Anschutz Medical Center, University of Colorado Denver, Aurora, Colorado, USA, 8Department of Health Evidence and Policy, Center for Biostatistics, Mount Sinai School of Medicine, New York, USA, 9Departments of Medicine and Public Health, Weill-Cornell Medical College, New York, USA, 10Radiology and Imaging Sciences, National Institutes of Health/Clinical Center, National Institute for Biomedical Imaging and Bioengineering, Bethesda, Maryland, USA, and 11Department of Medicine, Penn Cardiovascular Institute, and the Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA Funding Information: National Institutes of Health R01-HL086719, R01-HL077612, N01-HC95159 through N01-HC95169, American Heart Association 11FTF7400032, ASPIRE Pulmonary Vascular Disease Young Investigator Research Award WS1952812. Conflict of Interest: None declared. Publisher Copyright: {\textcopyright} 2012, Taylor and Francis Inc. All right reserved.",
year = "2012",
month = jul,
doi = "10.4103/2045-8932.101657",
language = "English (US)",
volume = "2",
pages = "379--386",
journal = "Pulmonary Circulation",
issn = "2045-8932",
publisher = "University of Chicago Press",
number = "3",
}