The relationship of blood lead to blood pressure in a longitudinal study of working men

S. T. Weiss; A. Muñoz; A. Stein; D. Sparrow; F. E. Speizer

doi:10.1093/oxfordjournals.aje.a114309

The relationship of blood lead to blood pressure in a longitudinal study of working men

S. T. Weiss, A. Muñoz, A. Stein, D. Sparrow, F. E. Speizer

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63 Scopus citations

Abstract

The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.

Original language	English (US)
Pages (from-to)	800-808
Number of pages	9
Journal	American journal of epidemiology
Volume	123
Issue number	5
DOIs	https://doi.org/10.1093/oxfordjournals.aje.a114309
State	Published - May 1986
Externally published	Yes

Keywords

Blood pressure
Hypertension
Lead
Longitudinal studies

ASJC Scopus subject areas

Epidemiology

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10.1093/oxfordjournals.aje.a114309

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title = "The relationship of blood lead to blood pressure in a longitudinal study of working men",

abstract = "The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.",

keywords = "Blood pressure, Hypertension, Lead, Longitudinal studies",

author = "Weiss, {S. T.} and A. Mu{\~n}oz and A. Stein and D. Sparrow and Speizer, {F. E.}",

note = "Funding Information: This work was supported in part by Clinical Investigator Award No. 00740 and Grant No. HL19170 from the Division of Lung Disease, National Heart, Lung and Blood Institute (Dr. Weiss).",

year = "1986",

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doi = "10.1093/oxfordjournals.aje.a114309",

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T1 - The relationship of blood lead to blood pressure in a longitudinal study of working men

AU - Weiss, S. T.

AU - Muñoz, A.

AU - Stein, A.

AU - Sparrow, D.

AU - Speizer, F. E.

N1 - Funding Information: This work was supported in part by Clinical Investigator Award No. 00740 and Grant No. HL19170 from the Division of Lung Disease, National Heart, Lung and Blood Institute (Dr. Weiss).

PY - 1986/5

Y1 - 1986/5

N2 - The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.

AB - The relationship of lead exposure to blood pressure has been examined in a longitudinal study of a cohort of 89 Boston, Massachusetts, policemen. At the baseline examination, subjects had a blood lead determination and three consecutive blood pressure measurements. Triplicate blood pressure measurements were also taken at years 3, 4, and 5. Multivariate analysis revealed that, after correction for previous systolic blood pressure, body mass index, age, and smoking, a high level of blood lead was a significant predictor of subsequent elevation of systolic pressure. Bootstrap simulations of these models provided supporting evidence for the observed associations. These data suggest that lead exposure can significantly affect systolic pressure.

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KW - Hypertension

KW - Lead

KW - Longitudinal studies

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The relationship of blood lead to blood pressure in a longitudinal study of working men

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Keywords

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