TY - JOUR
T1 - The relationship of airways responsiveness to cold air, cigarette smoking, and atopy to respiratory symptoms and pulmonary function in adults
AU - Welty, C.
AU - Weiss, S. T.
AU - Tager, I. B.
AU - Muñoz, A.
AU - Becker, C.
AU - Speizer, F. E.
AU - Ingram, R. H.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1984
Y1 - 1984
N2 - The response to eucapnic hyperventilation with subfreezing air was studied in a population based sample of 171 adults, all of whom also completed a respiratory questionnaire, spirometry, and skin testing. A positive response to the cold air challenge was defined as ((initial FEV1-postchallenge FEV1)/initial FVC) x 100) greater than or equal to 9%. Cigarette smoking was associated with a positive cold air response: 12 of 128 current and ex-smokers (9.4%) versus 1 of 43 nonsmokers (2.3%) (p = 0.095). Among current and ex-smokers, a positive response to the cold air challenge was significantly associated with asthma (p = 0.046). Using a logistic regression model, both current smoking and response to cold air were significant predictors of the presence of 'persistent wheeze' or asthma. A positive skin test to any of the 4 environmental antigens used (ragweed, housedust, trees, and grasses) was significantly associated with cigarette smoking (p = 0.018) and hay fever (p = 0.003 among current and ex-smokers) but not with wheezing or asthma. Though not statistically significant, cold air responders had a lower percentage of positive skin test reactivity than nonreactors. The findings of this cross-sectional analysis suggest that in adults, both airways responsiveness and cigarette smoking are important predictors of wheezing and asthma. Furthermore, the data suggest that airway hyperresponsiveness and atopy are independent traits. However, in adults, these traits are associated with cigarette smoking, a common environmental exposure.
AB - The response to eucapnic hyperventilation with subfreezing air was studied in a population based sample of 171 adults, all of whom also completed a respiratory questionnaire, spirometry, and skin testing. A positive response to the cold air challenge was defined as ((initial FEV1-postchallenge FEV1)/initial FVC) x 100) greater than or equal to 9%. Cigarette smoking was associated with a positive cold air response: 12 of 128 current and ex-smokers (9.4%) versus 1 of 43 nonsmokers (2.3%) (p = 0.095). Among current and ex-smokers, a positive response to the cold air challenge was significantly associated with asthma (p = 0.046). Using a logistic regression model, both current smoking and response to cold air were significant predictors of the presence of 'persistent wheeze' or asthma. A positive skin test to any of the 4 environmental antigens used (ragweed, housedust, trees, and grasses) was significantly associated with cigarette smoking (p = 0.018) and hay fever (p = 0.003 among current and ex-smokers) but not with wheezing or asthma. Though not statistically significant, cold air responders had a lower percentage of positive skin test reactivity than nonreactors. The findings of this cross-sectional analysis suggest that in adults, both airways responsiveness and cigarette smoking are important predictors of wheezing and asthma. Furthermore, the data suggest that airway hyperresponsiveness and atopy are independent traits. However, in adults, these traits are associated with cigarette smoking, a common environmental exposure.
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U2 - 10.1164/arrd.1984.130.2.198
DO - 10.1164/arrd.1984.130.2.198
M3 - Article
C2 - 6465674
AN - SCOPUS:0021182754
SN - 1073-449X
VL - 130
SP - 198
EP - 203
JO - American Review of Respiratory Disease
JF - American Review of Respiratory Disease
IS - 2
ER -