TY - JOUR
T1 - The relationship between insulin-sensitive obesity and cardiovascular diseases in a Chinese population
T2 - Results of the REACTION study
AU - Lu, Jieli
AU - Bi, Yufang
AU - Wang, Tiange
AU - Wang, Weiqing
AU - Mu, Yiming
AU - Zhao, Jiajun
AU - Liu, Chao
AU - Chen, Lulu
AU - Shi, Lixin
AU - Li, Qiang
AU - Wan, Qin
AU - Wu, Shengli
AU - Qin, Guijun
AU - Yang, Tao
AU - Yan, Li
AU - Liu, Yan
AU - Wang, Guixia
AU - Luo, Zuojie
AU - Tang, Xulei
AU - Chen, Gang
AU - Huo, Yanan
AU - Gao, Zhengnan
AU - Su, Qing
AU - Ye, Zhen
AU - Wang, Youming
AU - Deng, Huacong
AU - Yu, Xuefeng
AU - Shen, Feixia
AU - Chen, Li
AU - Zhao, Liebing
AU - Dai, Meng
AU - Xu, Min
AU - Xu, Yu
AU - Chen, Yuhong
AU - Lai, Shenghan
AU - Ning, Guang
N1 - Funding Information:
This work is supported by the Chinese Society of Endocrinology, the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health ( 1994DP131044 ), the National Key New Drug Creation and Manufacturing Program of Ministry of Science and Technology ( 2012ZX09303006-001 ), the National Clinical Research Center for Metabolic Diseases of Ministry of Health ( 2013BAI09B13 ), the EFSD-CDS-Lilly Program for Collaborative Research between China and Europe (2011), and the National Natural Science Foundation of China ( 81030011 , 81222008 , 81130016 ).
PY - 2014/3/15
Y1 - 2014/3/15
N2 - Objective Obesity and insulin resistance are risk factors for cardiovascular diseases. Whether insulin-sensitive obese individuals are at higher risk for cardiovascular diseases is still debated. We aim to investigate whether insulin-sensitive obesity associates with prevalent cardiovascular diseases and 10-year coronary heart disease (CHD) risk. Research design and methods At the baseline of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study, 211,641 participants aged 40 years or older were recruited from 25 communities across the China mainland, in 2011 to 2012. Participants were categorized by insulin-sensitive/resistant and general/abdominal obese status. Cardiovascular diseases included CHD, stroke, and myocardial infarction. Framingham risk score (FRS) was calculated according to National Cholesterol Education Program-Adult Treatment Panel III and FRS greater than 20% or cardiovascular diseases were identified as high risk for 10-year CHD. Results Controlling for potential confounders, compared with insulin-sensitive normal weight individuals, insulin-sensitive general obese individuals had increased risks for prevalent cardiovascular diseases (men: OR, 2.55, 95% CI, 2.04-3.18; women: 1.73, 1.45-2.06) and 10-year Framingham risk for CHD (men: 2.26, 1.86-2.76; women: 1.73, 1.46-2.06). Compared with insulin-sensitive normal waist subgroup, insulin-sensitive abdominal obesity was associated with higher risks for prevalent cardiovascular diseases (men: 1.32, 1.20-1.46; women: 1.36, 1.27-1.47) and 10-year Framingham risk for CHD (men, 1.34, 1.23-1.45; women, 1.37, 1.27-1.47). Conclusion Both general and abdominal obesity were associated with elevated prevalent cardiovascular diseases and 10-year CHD risk, regardless of the presence or absence of insulin resistance.
AB - Objective Obesity and insulin resistance are risk factors for cardiovascular diseases. Whether insulin-sensitive obese individuals are at higher risk for cardiovascular diseases is still debated. We aim to investigate whether insulin-sensitive obesity associates with prevalent cardiovascular diseases and 10-year coronary heart disease (CHD) risk. Research design and methods At the baseline of the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal (REACTION) study, 211,641 participants aged 40 years or older were recruited from 25 communities across the China mainland, in 2011 to 2012. Participants were categorized by insulin-sensitive/resistant and general/abdominal obese status. Cardiovascular diseases included CHD, stroke, and myocardial infarction. Framingham risk score (FRS) was calculated according to National Cholesterol Education Program-Adult Treatment Panel III and FRS greater than 20% or cardiovascular diseases were identified as high risk for 10-year CHD. Results Controlling for potential confounders, compared with insulin-sensitive normal weight individuals, insulin-sensitive general obese individuals had increased risks for prevalent cardiovascular diseases (men: OR, 2.55, 95% CI, 2.04-3.18; women: 1.73, 1.45-2.06) and 10-year Framingham risk for CHD (men: 2.26, 1.86-2.76; women: 1.73, 1.46-2.06). Compared with insulin-sensitive normal waist subgroup, insulin-sensitive abdominal obesity was associated with higher risks for prevalent cardiovascular diseases (men: 1.32, 1.20-1.46; women: 1.36, 1.27-1.47) and 10-year Framingham risk for CHD (men, 1.34, 1.23-1.45; women, 1.37, 1.27-1.47). Conclusion Both general and abdominal obesity were associated with elevated prevalent cardiovascular diseases and 10-year CHD risk, regardless of the presence or absence of insulin resistance.
KW - Cardiovascular diseases
KW - Epidemiology
KW - Insulin resistance
KW - Obesity
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U2 - 10.1016/j.ijcard.2014.01.073
DO - 10.1016/j.ijcard.2014.01.073
M3 - Article
C2 - 24502884
AN - SCOPUS:84900572698
SN - 0167-5273
VL - 172
SP - 388
EP - 394
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 2
ER -