The relationship between Graves’ ophthalmopathy and dry eye syndrome

Jessica H. Selter; Anisa I. Gire; Shameema Sikder

doi:10.2147/OPTH.S76583

The relationship between Graves’ ophthalmopathy and dry eye syndrome

Jessica H. Selter, Anisa I. Gire, Shameema Sikder

School of Medicine

Research output: Contribution to journal › Review article › peer-review

17 Scopus citations

Abstract

Background: A complex relationship between Graves’ ophthalmopathy (GO) and dry eye syndrome exists. New research brings more insight into the association between these two diseases.

Methods: A review of the literature was conducted using the query terms “Graves’ Ophthal-mopathy”, “Thyroid Eye Disease”, and “Dry Eye” in MedLine (PubMed) and Scopus. A total of 55 papers were reviewed. Case reports were excluded.

Conclusion: This review paper shows the close relationship between dry eye syndrome and GO. The underlying mechanisms behind their association suggest mechanical impairment of orbital muscles and immune-mediated lacrimal gland dysfunction as the causes of dry eye in GO patients. However, there are a variety of treatment options available for patients with GO with signs of dry eye, which help combat this issue.

Original language	English (US)
Pages (from-to)	57-62
Number of pages	6
Journal	Clinical Ophthalmology
Volume	9
DOIs	https://doi.org/10.2147/OPTH.S76583
State	Published - Dec 31 2014

Keywords

Dry eye
Graves’ ophthalmopathy
Ocular inflammation
Thyroid eye disease

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.2147/OPTH.S76583

Cite this

@article{0e592cd081c14f7790be3711ada12eb1,

title = "The relationship between Graves{\textquoteright} ophthalmopathy and dry eye syndrome",

abstract = "Background: A complex relationship between Graves{\textquoteright} ophthalmopathy (GO) and dry eye syndrome exists. New research brings more insight into the association between these two diseases.Methods: A review of the literature was conducted using the query terms “Graves{\textquoteright} Ophthal-mopathy”, “Thyroid Eye Disease”, and “Dry Eye” in MedLine (PubMed) and Scopus. A total of 55 papers were reviewed. Case reports were excluded.Conclusion: This review paper shows the close relationship between dry eye syndrome and GO. The underlying mechanisms behind their association suggest mechanical impairment of orbital muscles and immune-mediated lacrimal gland dysfunction as the causes of dry eye in GO patients. However, there are a variety of treatment options available for patients with GO with signs of dry eye, which help combat this issue.",

keywords = "Dry eye, Graves{\textquoteright} ophthalmopathy, Ocular inflammation, Thyroid eye disease",

author = "Selter, {Jessica H.} and Gire, {Anisa I.} and Shameema Sikder",

note = "Publisher Copyright: {\textcopyright} 2015 Selter et al.",

year = "2014",

month = dec,

day = "31",

doi = "10.2147/OPTH.S76583",

language = "English (US)",

volume = "9",

pages = "57--62",

journal = "Clinical Ophthalmology",

issn = "1177-5467",

publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - The relationship between Graves’ ophthalmopathy and dry eye syndrome

AU - Selter, Jessica H.

AU - Gire, Anisa I.

AU - Sikder, Shameema

PY - 2014/12/31

Y1 - 2014/12/31

N2 - Background: A complex relationship between Graves’ ophthalmopathy (GO) and dry eye syndrome exists. New research brings more insight into the association between these two diseases.Methods: A review of the literature was conducted using the query terms “Graves’ Ophthal-mopathy”, “Thyroid Eye Disease”, and “Dry Eye” in MedLine (PubMed) and Scopus. A total of 55 papers were reviewed. Case reports were excluded.Conclusion: This review paper shows the close relationship between dry eye syndrome and GO. The underlying mechanisms behind their association suggest mechanical impairment of orbital muscles and immune-mediated lacrimal gland dysfunction as the causes of dry eye in GO patients. However, there are a variety of treatment options available for patients with GO with signs of dry eye, which help combat this issue.

AB - Background: A complex relationship between Graves’ ophthalmopathy (GO) and dry eye syndrome exists. New research brings more insight into the association between these two diseases.Methods: A review of the literature was conducted using the query terms “Graves’ Ophthal-mopathy”, “Thyroid Eye Disease”, and “Dry Eye” in MedLine (PubMed) and Scopus. A total of 55 papers were reviewed. Case reports were excluded.Conclusion: This review paper shows the close relationship between dry eye syndrome and GO. The underlying mechanisms behind their association suggest mechanical impairment of orbital muscles and immune-mediated lacrimal gland dysfunction as the causes of dry eye in GO patients. However, there are a variety of treatment options available for patients with GO with signs of dry eye, which help combat this issue.

KW - Dry eye

KW - Graves’ ophthalmopathy

KW - Ocular inflammation

KW - Thyroid eye disease

UR - http://www.scopus.com/inward/record.url?scp=84920500607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84920500607&partnerID=8YFLogxK

U2 - 10.2147/OPTH.S76583

DO - 10.2147/OPTH.S76583

M3 - Review article

C2 - 25584018

AN - SCOPUS:84920500607

SN - 1177-5467

VL - 9

SP - 57

EP - 62

JO - Clinical Ophthalmology

JF - Clinical Ophthalmology

ER -

The relationship between Graves’ ophthalmopathy and dry eye syndrome

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this