The reaction of myelin phospholipids with phospholipase C and D

M. Guarnieri, H. Syed, W. Weintraub, G. M. McKhann

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Phospholipase C and D hydrolyze the membrane-bound phospholipids of isolated, untreated myelin. When the membrane is treated with detergents or solvents which disrupt the membrane structure, the activity of the enzymes against the membrane-bound lipids increases. Myelin in the central nervous system is derived from the cell membrane of the oligodendroglial cell. Because the phospholipids in erythrocyte cell membranes are strikingly resistent to phospholipase C and D hydrolysis the question is raised of whether myelin in situ, as opposed to isolated myelin, is susceptible to phospholipase hydrolysis.

Original languageEnglish (US)
Pages (from-to)581-587
Number of pages7
JournalArchives of Biochemistry and Biophysics
Issue number2
StatePublished - Apr 1975

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology


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