The question of a role for statins in age-related macular degeneration

Marina Roizenblatt, Nara Naranjit, Mauricio Maia, Peter L. Gehlbach

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Age-related macular degeneration (AMD) is the leading cause of irreversible central vision loss in patients over the age of 65 years in industrialized countries. Epidemiologic studies suggest that high dietary fat intake is a risk factor for the development and progression of both vascular and retinal disease. These, and other associations, suggest a hypothesis linking elevated cholesterol and AMD progression. It follows, therefore, that cholesterol-lowering medications, such as statins, may influence the onset and progression of AMD. However, the findings have been inconclusive as to whether statins play a role in AMD. Due to the significant public health implications of a potential inhibitory effect of statins on the onset and progression of AMD, it is important to continually evaluate emerging findings germane to this question.

Original languageEnglish (US)
Article number3688
JournalInternational journal of molecular sciences
Issue number11
StatePublished - Nov 2018


  • Age-related macular degeneration
  • Atherosclerotic disease
  • Cholesterol
  • Retina
  • Statins

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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