The pursuit of effective neuroprotection during infant cardiac surgery

A. J. Du Piessis, M. V. Johnston

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Advances in infant cardiac surgery have resulted in a dramatic decline in mortality rates; however, neurological morbidity remains an important concern. The effectiveness of a number of interventional strategies to prevent or minimize brain injury during open heart surgery are currently being investigated. This article provides an overview of two approaches: (1) interventions to enhance intraoperative cerebral oxygenation so as to prevent hypoxic-ischemic insults, and (2) the application of cerebral rescue therapies to attenuate the cascade of brain injury. Infant cardiac surgery provides a controlled environment in which to apply these neuroprotective approaches, so as to optimize the quality of life of these vulnerable children.

Original languageEnglish (US)
Pages (from-to)55-63
Number of pages9
JournalSeminars in Pediatric Neurology
Issue number1
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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