TY - JOUR
T1 - The prostate cancer bone marrow niche
T2 - More than just fertile soil
AU - Pedersen, Elisabeth A.
AU - Shiozawa, Yusuke
AU - Pienta, Kenneth J.
AU - Taichman, Russell S.
PY - 2012/5
Y1 - 2012/5
N2 - The hematopoietic stem cell (HSC) niche in the bone marrow has been studied extensively over the past few decades, yet the bone marrow microenvironment that supports the growth of metastatic prostate cancer (PCa) has only been recently considered to be a specialized 'niche' as well. New evidence supports the fact that disseminated tumor cells (DTCs) of PCa actually target the HSC niche, displace the occupant HSCs and take up residence in the pre-existing niche space. This review describes some of the evidence and mechanisms by which DTCs act as molecular parasites of the HSC niche. Furthermore, the interactions between DTCs, HSCs and the niche may provide new targets for niche-directed therapy, as well as insight into the perplexing clinical manifestations of metastatic PCa disease.
AB - The hematopoietic stem cell (HSC) niche in the bone marrow has been studied extensively over the past few decades, yet the bone marrow microenvironment that supports the growth of metastatic prostate cancer (PCa) has only been recently considered to be a specialized 'niche' as well. New evidence supports the fact that disseminated tumor cells (DTCs) of PCa actually target the HSC niche, displace the occupant HSCs and take up residence in the pre-existing niche space. This review describes some of the evidence and mechanisms by which DTCs act as molecular parasites of the HSC niche. Furthermore, the interactions between DTCs, HSCs and the niche may provide new targets for niche-directed therapy, as well as insight into the perplexing clinical manifestations of metastatic PCa disease.
KW - dormancy
KW - hematopoietic stem cell
KW - metastasis
KW - niche
KW - osteoblasts
KW - prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=84860851484&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860851484&partnerID=8YFLogxK
U2 - 10.1038/aja.2011.164
DO - 10.1038/aja.2011.164
M3 - Review article
C2 - 22367179
AN - SCOPUS:84860851484
SN - 1008-682X
VL - 14
SP - 423
EP - 427
JO - Asian Journal of Andrology
JF - Asian Journal of Andrology
IS - 3
ER -