The Prognostic Value of Signet-Ring Cell Histology in Resected Gastric Adenocarcinoma

Lauren M. Postlewait, Malcolm H. Squires, David A. Kooby, George A. Poultsides, Sharon M. Weber, Mark Bloomston, Ryan C. Fields, Timothy M. Pawlik, Konstantinos I. Votanopoulos, Carl R. Schmidt, Aslam Ejaz, Alexandra W. Acher, David J. Worhunsky, Neil Saunders, Douglas Swords, Linda X. Jin, Clifford S. Cho, Emily R. Winslow, Kenneth Cardona, Charles A. StaleyShishir K. Maithel

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background: Conflicting data exist on the prognostic implication of signet-ring cell (SRC) histology in gastric adenocarcinoma (GAC). Methods: All patients who underwent curative-intent resection of GAC from the seven institutions of the U.S. Gastric Cancer Collaborative between 2000 and 2012 were included. Primary end points were recurrence-free survival (RFS) and overall survival (OS). Stage-specific analyses were performed. Results: A total of 768 patients met the inclusion criteria. SRC was present in 40.6 % of patients and was associated with female sex (52.9 vs. 38.6 %; p 

Original languageEnglish (US)
Pages (from-to)832-839
Number of pages8
JournalAnnals of Surgical Oncology
StatePublished - Dec 1 2015

ASJC Scopus subject areas

  • Surgery
  • Oncology


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