The Problem of Neurovascular Uncoupling

Research output: Contribution to journalReview articlepeer-review


Neurovascular uncoupling (NVU) is one of the most important confounds of blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMR imaging) in the setting of focal brain lesions such as brain tumors. This article reviews the assessment of NVU related to focal brain lesions with emphasis on the use of cerebrovascular reactivity mapping measurement methods and resting state BOLD fMR imaging metrics in the detection of NVU, as well as the use of amplitude of low-frequency fluctuation metrics to mitigate the effects of NVU on clinical fMR imaging activation.

Original languageEnglish (US)
Pages (from-to)53-67
Number of pages15
JournalNeuroimaging Clinics of North America
Issue number1
StatePublished - Feb 2021


  • Motor activation
  • Neurovascular uncoupling
  • Presurgical mapping

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging


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